Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1.

Shi, Zhong-Dong; Ji, Xin-Ying; Qazi, Henry; Tarbell, John M

Shi, Zhong-Dong; Ji, Xin-Ying; Qazi, Henry; Tarbell, John M.

Affiliation

Shi ZD; Department of Biomedical Engineering, City College of New York, City University of New York, New York 10031, USA.

Am J Physiol Heart Circ Physiol ; 297(4): H1225-34, 2009 10.

Article in En | MEDLINE | ID: mdl-19465549

Subject(s)

Cell Movement; Collagen Type I/metabolism; Fibroblasts/enzymology; Matrix Metalloproteinase 1/metabolism; Mechanotransduction, Cellular; Muscle, Smooth, Vascular/enzymology; Myocytes, Smooth Muscle/enzymology; Pulsatile Flow; Animals; Apoptosis; Blood Pressure; Cell Movement/drug effects; Cells, Cultured; Dipeptides/pharmacology; Fibroblasts/drug effects; Fibroblasts/pathology; Gels; Matrix Metalloproteinase 1/genetics; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase Inhibitors; Mechanotransduction, Cellular/drug effects; Models, Biological; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/pathology; Necrosis; Permeability; Protease Inhibitors/pharmacology; RNA Interference; Rats; Rheology; Stress, Mechanical; Tissue Inhibitor of Metalloproteinase-1/metabolism; Up-Regulation

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulsatile Flow / Cell Movement / Matrix Metalloproteinase 1 / Collagen Type I / Myocytes, Smooth Muscle / Mechanotransduction, Cellular / Fibroblasts / Muscle, Smooth, Vascular Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2009 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google