Mechanistic and structural insights into the proteolytic  activation of Vibrio cholerae MARTX toxin.

Shen, Aimee; Lupardus, Patrick J; Albrow, Victoria E; Guzzetta, Andrew; Powers, James C; Garcia, K Christopher; Bogyo, Matthew

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.

Shen, Aimee; Lupardus, Patrick J; Albrow, Victoria E; Guzzetta, Andrew; Powers, James C; Garcia, K Christopher; Bogyo, Matthew.

Affiliation

Shen A; Department of Pathology, and Howard Hughes Medical Institute, Stanford School of Medicine, Stanford,California, USA.

Nat Chem Biol ; 5(7): 469-78, 2009 Jul.

Article in En | MEDLINE | ID: mdl-19465933

Subject(s)

Cholera Toxin/chemistry; Cholera Toxin/metabolism; Cysteine Proteases/metabolism; Cysteine Proteinase Inhibitors/pharmacology; Vibrio cholerae/metabolism; Allosteric Regulation; Amino Acid Sequence; Blotting, Western; Catalytic Domain; Crystallography, X-Ray; Enzyme Activation/drug effects; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Sequence Alignment; Spectroscopy, Fourier Transform Infrared; Substrate Specificity; Vibrio cholerae/drug effects; Vibrio cholerae/enzymology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vibrio cholerae / Cysteine Proteinase Inhibitors / Cholera Toxin / Cysteine Proteases Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

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