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Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression.
Neff, Chris D; Abkevich, Victor; Potter, Jennifer; Riley, Robin; Shattuck, Donna; Katz, David A.
Affiliation
  • Neff CD; Myriad Genetics, Salt Lake City, Utah, USA.
Am J Med Genet B Neuropsychiatr Genet ; 153B(1): 321-2, 2010 Jan 05.
Article in En | MEDLINE | ID: mdl-19475634
Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 4 / Depressive Disorder, Major / Epistasis, Genetic / Serotonin Plasma Membrane Transport Proteins Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Am J Med Genet B Neuropsychiatr Genet Journal subject: GENETICA MEDICA / NEUROLOGIA / PSIQUIATRIA Year: 2010 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 4 / Depressive Disorder, Major / Epistasis, Genetic / Serotonin Plasma Membrane Transport Proteins Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Am J Med Genet B Neuropsychiatr Genet Journal subject: GENETICA MEDICA / NEUROLOGIA / PSIQUIATRIA Year: 2010 Type: Article Affiliation country: United States