Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression.
Am J Med Genet B Neuropsychiatr Genet
; 153B(1): 321-2, 2010 Jan 05.
Article
in En
| MEDLINE
| ID: mdl-19475634
Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 4
/
Depressive Disorder, Major
/
Epistasis, Genetic
/
Serotonin Plasma Membrane Transport Proteins
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Am J Med Genet B Neuropsychiatr Genet
Journal subject:
GENETICA MEDICA
/
NEUROLOGIA
/
PSIQUIATRIA
Year:
2010
Type:
Article
Affiliation country:
United States