Design, synthesis and identification of novel colchicine-derived immunosuppressant.

Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger

Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger.

Affiliation

Chang DJ; College of Pharmacy, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul 151-742, Republic of Korea.

Bioorg Med Chem Lett ; 19(15): 4416-20, 2009 Aug 01.

Article in En | MEDLINE | ID: mdl-19502058

Subject(s)

Colchicine/analogs & derivatives; Immunosuppressive Agents/chemical synthesis; Animals; Autoimmune Diseases/drug therapy; Chemistry, Pharmaceutical/methods; Colchicine/chemical synthesis; Colchicine/pharmacology; Cyclosporine/pharmacology; Drug Design; Gout Suppressants/chemical synthesis; Gout Suppressants/pharmacology; Graft Rejection; Humans; Immunosuppressive Agents/pharmacology; Inflammation; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Skin Transplantation; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colchicine / Immunosuppressive Agents Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article

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