p62 at the crossroads of autophagy, apoptosis, and cancer.
Cell
; 137(6): 1001-4, 2009 Jun 12.
Article
in En
| MEDLINE
| ID: mdl-19524504
ABSTRACT
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Apoptosis
/
Adaptor Proteins, Signal Transducing
/
Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Cell
Year:
2009
Type:
Article
Affiliation country:
United States