The presumed hyporesponsive behavior of rheumatoid arthritis T lymphocytes can be attributed to spontaneous ex vivo apoptosis rather than defects in T cell receptor signaling.

Abreu, Joana R F; Grabiec, Aleksander M; Krausz, Sarah; Spijker, René; Burakowski, Tomasz; Maslinski, Wlodzimierz; Eldering, Eric; Tak, Paul P; Reedquist, Kris A

Abreu, Joana R F; Grabiec, Aleksander M; Krausz, Sarah; Spijker, René; Burakowski, Tomasz; Maslinski, Wlodzimierz; Eldering, Eric; Tak, Paul P; Reedquist, Kris A.

Affiliation

Abreu JR; Academic Medical Center, University of Amsterdam, The Netherlands.

J Immunol ; 183(1): 621-30, 2009 Jul 01.

Article in En | MEDLINE | ID: mdl-19525395

Subject(s)

Apoptosis/immunology; Arthritis, Rheumatoid/immunology; Arthritis, Rheumatoid/metabolism; Receptors, Antigen, T-Cell/physiology; Signal Transduction/immunology; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid/pathology; Cell Proliferation; Cells, Cultured; Female; Humans; Male; Middle Aged; Receptors, Antigen, T-Cell/deficiency; Synovial Fluid/immunology; Synovial Fluid/metabolism; T-Lymphocyte Subsets/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Receptors, Antigen, T-Cell / Signal Transduction / T-Lymphocyte Subsets / Apoptosis Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Immunol Year: 2009 Type: Article Affiliation country: Netherlands

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