Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal.

Soncin, Francesca; Mohamet, Lisa; Eckardt, Dominik; Ritson, Sarah; Eastham, Angela M; Bobola, Nicoletta; Russell, Angela; Davies, Steve; Kemler, Rolf; Merry, Catherine L R; Ward, Christopher M

Soncin, Francesca; Mohamet, Lisa; Eckardt, Dominik; Ritson, Sarah; Eastham, Angela M; Bobola, Nicoletta; Russell, Angela; Davies, Steve; Kemler, Rolf; Merry, Catherine L R; Ward, Christopher M.

Affiliation

Soncin F; Core Technology Facility, Faculty of Medical and Human Sciences, and The University of Manchester, Manchester, United Kingdom.

Stem Cells ; 27(9): 2069-80, 2009 Sep.

Article in En | MEDLINE | ID: mdl-19544408

Subject(s)

Cadherins/physiology; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Leukemia Inhibitory Factor/pharmacology; Activins/pharmacology; Animals; Cadherins/genetics; Cadherins/metabolism; Cattle; Cell Communication/drug effects; Cell Communication/genetics; Cell Differentiation/drug effects; Cell Differentiation/genetics; Cells, Cultured; Embryonic Stem Cells/drug effects; Fibroblast Growth Factor 2/pharmacology; Flow Cytometry; Fluorescent Antibody Technique; Mice; Nodal Protein/pharmacology; Protein Multimerization/genetics; Protein Multimerization/physiology; RNA Interference; Reverse Transcriptase Polymerase Chain Reaction; beta Catenin/genetics; beta Catenin/metabolism; beta Catenin/physiology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cadherins / Embryonic Stem Cells / Leukemia Inhibitory Factor Limits: Animals Language: En Journal: Stem Cells Year: 2009 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google