Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists.

Robben, Joris H; Kortenoeven, Marleen L A; Sze, Mozes; Yae, Chris; Milligan, Graeme; Oorschot, Viola M; Klumperman, Judith; Knoers, Nine V A M; Deen, Peter M T

Robben, Joris H; Kortenoeven, Marleen L A; Sze, Mozes; Yae, Chris; Milligan, Graeme; Oorschot, Viola M; Klumperman, Judith; Knoers, Nine V A M; Deen, Peter M T.

Affiliation

Robben JH; Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500HB Nijmegen, The Netherlands.

Proc Natl Acad Sci U S A ; 106(29): 12195-200, 2009 Jul 21.

Article in En | MEDLINE | ID: mdl-19587238

Subject(s)

Diabetes Insipidus, Nephrogenic/metabolism; Intracellular Space/metabolism; Mutant Proteins/metabolism; Peptides/pharmacology; Receptors, Vasopressin/agonists; Receptors, Vasopressin/metabolism; Animals; Aquaporin 2/metabolism; Cell Line; Cell Membrane/drug effects; Cell Membrane/metabolism; Cell Polarity/drug effects; Deamino Arginine Vasopressin/pharmacology; Dogs; Humans; Intracellular Space/drug effects; Protein Stability/drug effects; Protein Transport/drug effects; Receptors, Vasopressin/ultrastructure; Recombinant Fusion Proteins/metabolism; Subcellular Fractions/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Receptors, Vasopressin / Diabetes Insipidus, Nephrogenic / Intracellular Space / Mutant Proteins Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2009 Type: Article Affiliation country: Netherlands

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