Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.

Olimpieri, Francesca; Tambaro, Simone; Fustero, Santos; Lazzari, Paolo; Sanchez-Roselló, Maria; Pani, Luca; Volonterio, Alessandro; Zanda, Matteo

Olimpieri, Francesca; Tambaro, Simone; Fustero, Santos; Lazzari, Paolo; Sanchez-Roselló, Maria; Pani, Luca; Volonterio, Alessandro; Zanda, Matteo.

Affiliation

Olimpieri F; Dipartimento di Chimica, Materiali, e Ingegneria Chimica Giulio Natta, 20131 Milano, Italy.

Bioorg Med Chem Lett ; 19(16): 4715-9, 2009 Aug 15.

Article in En | MEDLINE | ID: mdl-19596577

Subject(s)

Angiotensin-Converting Enzyme Inhibitors/chemical synthesis; Fluorine/chemistry; Neprilysin/antagonists & inhibitors; Peptidyl-Dipeptidase A/chemistry; Protease Inhibitors/chemical synthesis; Sulfhydryl Compounds/chemical synthesis; Angiotensin-Converting Enzyme Inhibitors/chemistry; Angiotensin-Converting Enzyme Inhibitors/pharmacology; Humans; Neprilysin/metabolism; Peptides/chemistry; Peptidyl-Dipeptidase A/metabolism; Protease Inhibitors/chemistry; Protease Inhibitors/pharmacology; Sulfhydryl Compounds/chemistry; Sulfhydryl Compounds/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Sulfhydryl Compounds / Angiotensin-Converting Enzyme Inhibitors / Neprilysin / Peptidyl-Dipeptidase A / Fluorine Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: Italy

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