Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists.

Washburn, David G; Hoang, Tram H; Frazee, James S; Johnson, Latisha; Hammond, Marlys; Manns, Sharada; Madauss, Kevin P; Williams, Shawn P; Duraiswami, Chaya; Tran, Thuy B; Stewart, Eugene L; Grygielko, Eugene T; Glace, Lindsay E; Trizna, Walter; Nagilla, Rakesh; Bray, Jeffrey D; Thompson, Scott K

Washburn, David G; Hoang, Tram H; Frazee, James S; Johnson, Latisha; Hammond, Marlys; Manns, Sharada; Madauss, Kevin P; Williams, Shawn P; Duraiswami, Chaya; Tran, Thuy B; Stewart, Eugene L; Grygielko, Eugene T; Glace, Lindsay E; Trizna, Walter; Nagilla, Rakesh; Bray, Jeffrey D; Thompson, Scott K.

Affiliation

Washburn DG; Department of Chemistry, Metabolic Pathways Centre for Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA. dave.g.washburn@gsk.com

Bioorg Med Chem Lett ; 19(16): 4664-8, 2009 Aug 15.

Article in En | MEDLINE | ID: mdl-19616429

Subject(s)

Pyrrolidinones/chemistry; Receptors, Progesterone/agonists; Administration, Oral; Animals; Binding Sites; Drug Discovery; Ether-A-Go-Go Potassium Channels/metabolism; Haplorhini; Humans; Pyrrolidinones/chemical synthesis; Pyrrolidinones/pharmacokinetics; Rats; Receptors, Progesterone/metabolism; Structure-Activity Relationship

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidinones / Receptors, Progesterone Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google