Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease.

Auffret, Alexandra; Gautheron, Vanessa; Repici, Mariaelena; Kraftsik, Rudolf; Mount, Howard T J; Mariani, Jean; Rovira, Catherine

Auffret, Alexandra; Gautheron, Vanessa; Repici, Mariaelena; Kraftsik, Rudolf; Mount, Howard T J; Mariani, Jean; Rovira, Catherine.

Affiliation

Auffret A; Université Pierre et Marie Curie-Paris, Centre National de la Recherche Scientifique, France. alexandraauffret@gmail.com

J Neurosci ; 29(32): 10144-52, 2009 Aug 12.

Article in En | MEDLINE | ID: mdl-19675248

Subject(s)

Aging; Dendritic Spines/physiology; Hippocampus/physiology; Neuronal Plasticity/physiology; Neurons/physiology; Presenilin-1/metabolism; Alzheimer Disease/genetics; Animals; Cell Death; Dendritic Spines/genetics; Disease Models, Animal; Hippocampus/cytology; Humans; In Vitro Techniques; Long-Term Potentiation/genetics; Long-Term Potentiation/physiology; Male; Mice; Mice, Transgenic; Mutation, Missense; Neuronal Plasticity/genetics; Neurons/cytology; Presenilin-1/genetics; Receptors, N-Methyl-D-Aspartate/metabolism; Synapses/genetics; Synapses/physiology; Synaptic Transmission/genetics; Synaptic Transmission/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Dendritic Spines / Presenilin-1 / Hippocampus / Neuronal Plasticity / Neurons Limits: Animals / Humans / Male Language: En Journal: J Neurosci Year: 2009 Type: Article Affiliation country: France

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