P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.

Lee, Mike; Choi, Sungwon; Halldén, Gunnel; Yo, Sek Jin; Schichnes, Denise; Aponte, Gregory W

Lee, Mike; Choi, Sungwon; Halldén, Gunnel; Yo, Sek Jin; Schichnes, Denise; Aponte, Gregory W.

Affiliation

Lee M; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley, California 94720-3104, USA.

Am J Physiol Gastrointest Liver Physiol ; 297(4): G641-54, 2009 Oct.

Article in En | MEDLINE | ID: mdl-19679818

Subject(s)

Cell Adhesion; Epithelial Cells/metabolism; GTP-Binding Protein alpha Subunits, G12-G13/metabolism; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism; Intestinal Mucosa/metabolism; Lysophospholipids/metabolism; Receptors, Purinergic P2/metabolism; Animals; CHO Cells; Calcium Signaling; Cell Adhesion/drug effects; Cricetinae; Cricetulus; Down-Regulation; Enzyme Inhibitors/pharmacology; Epithelial Cells/drug effects; ErbB Receptors/metabolism; G-Protein-Coupled Receptor Kinase 2/genetics; G-Protein-Coupled Receptor Kinase 2/metabolism; GTP-Binding Protein alpha Subunits, G12-G13/antagonists & inhibitors; GTP-Binding Protein alpha Subunits, G12-G13/genetics; GTP-Binding Protein alpha Subunits, Gi-Go/antagonists & inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go/genetics; Guanine Nucleotide Exchange Factors/genetics; Guanine Nucleotide Exchange Factors/metabolism; HeLa Cells; Humans; Intestinal Mucosa/drug effects; MAP Kinase Kinase 1/metabolism; MAP Kinase Kinase 2/metabolism; Male; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Phosphorylation; Polyisoprenyl Phosphates/metabolism; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Purinergic P2/genetics; Recombinant Fusion Proteins/metabolism; Rho Guanine Nucleotide Exchange Factors; Serum Response Element; Sesquiterpenes/metabolism; Transfection; rho GTP-Binding Proteins/metabolism; rho-Associated Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lysophospholipids / Cell Adhesion / Receptors, Purinergic P2 / GTP-Binding Protein alpha Subunits, Gi-Go / GTP-Binding Protein alpha Subunits, G12-G13 / Epithelial Cells / Intestinal Mucosa Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2009 Type: Article Affiliation country: United States

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