Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.

Shao, Pengcheng P; Ye, Feng; Weber, Ann E; Li, Xiaohua; Lyons, Kathryn A; Parsons, William H; Garcia, Maria L; Priest, Birgit T; Smith, McHardy M; Felix, John P; Williams, Brande S; Kaczorowski, Gregory J; McGowan, Erin; Abbadie, Catherine; Martin, William J; McMasters, Daniel R; Gao, Ying-Duo

Shao, Pengcheng P; Ye, Feng; Weber, Ann E; Li, Xiaohua; Lyons, Kathryn A; Parsons, William H; Garcia, Maria L; Priest, Birgit T; Smith, McHardy M; Felix, John P; Williams, Brande S; Kaczorowski, Gregory J; McGowan, Erin; Abbadie, Catherine; Martin, William J; McMasters, Daniel R; Gao, Ying-Duo.

Affiliation

Shao PP; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. pengcheng_shao@merck.com

Bioorg Med Chem Lett ; 19(18): 5334-8, 2009 Sep 15.

Article in En | MEDLINE | ID: mdl-19683443

Subject(s)

Isoxazoles/therapeutic use; Pain/drug therapy; Sodium Channel Blockers/therapeutic use; Sodium Channels/metabolism; Animals; Cell Line; Chronic Disease; Humans; Isoxazoles/chemistry; Isoxazoles/pharmacology; Pain/immunology; Rats; Sodium Channel Blockers/chemistry; Sodium Channel Blockers/pharmacology; Spinal Nerves/drug effects; Structure-Activity Relationship

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Sodium Channels / Sodium Channel Blockers / Isoxazoles Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google