HTS and hit finding in academia--from chemical genomics to drug discovery.
Drug Discov Today
; 14(23-24): 1150-8, 2009 Dec.
Article
in En
| MEDLINE
| ID: mdl-19793546
ABSTRACT
The liaison between academia and the pharmaceutical industry was originally served primarily through the scientific literature and limited, specific industry-academia partnerships. Some of these partnerships have resulted in drugs on the market, such as Vorinostat (Memorial Sloan-Kettering Cancer Centre and Merck) and Tenofovir (University of Leuven; Institute of Organic Chemistry and Biochemistry, Czech Republic; and GlaxoSmithKline), but the timescales from concept to clinic have, in most cases, taken many decades. We now find ourselves in a world in which the edges between these sectors are more blurred and the establishment and acceptance of high-throughput screening alongside the wider concept of 'hit discovery' in academia provides one of the key platforms required to enable this sector to contribute directly to addressing unmet medical need.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Industry
/
Academies and Institutes
/
Drug Discovery
/
Interinstitutional Relations
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Drug Discov Today
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2009
Type:
Article
Affiliation country:
United kingdom