Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits.

Boullier, Séverine; Tanguy, Myriam; Kadaoui, Khalil A; Caubet, Cécile; Sansonetti, Philippe; Corthésy, Blaise; Phalipon, Armelle

Boullier, Séverine; Tanguy, Myriam; Kadaoui, Khalil A; Caubet, Cécile; Sansonetti, Philippe; Corthésy, Blaise; Phalipon, Armelle.

Affiliation

Boullier S; Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1225, Toulouse, France.

J Immunol ; 183(9): 5879-85, 2009 Nov 01.

Article in En | MEDLINE | ID: mdl-19828639

Subject(s)

Down-Regulation/immunology; Dysentery, Bacillary/immunology; Dysentery, Bacillary/pathology; Immunoglobulin A, Secretory/physiology; Inflammation Mediators/antagonists & inhibitors; Intestinal Mucosa/immunology; Intestinal Mucosa/pathology; Shigella flexneri/immunology; Animals; Antibody Specificity; Cell Membrane Permeability/immunology; Disease Models, Animal; Dysentery, Bacillary/prevention & control; Humans; Ileum/immunology; Ileum/metabolism; Ileum/microbiology; Ileum/pathology; Intestinal Mucosa/metabolism; Intestinal Mucosa/microbiology; Lipopolysaccharides/antagonists & inhibitors; Rabbits; Shigella flexneri/growth & development

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Shigella flexneri / Immunoglobulin A, Secretory / Down-Regulation / Inflammation Mediators / Dysentery, Bacillary / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2009 Type: Article Affiliation country: France

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