High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission.
J Infect Dis
; 200(10): 1498-502, 2009 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-19835475
ABSTRACT
Given the central role that interleukin 15 (IL-15) plays in human immunodeficiency virus (HIV) immunity, we hypothesized that IL-15 in breast milk may protect against postnatal HIV transmission. In a nested case-control study, we compared breast milk IL-15 levels in 22 HIV-infected women who transmitted HIV to their infants to those in 72 nontransmitters. Samples were collected in the first month of life, prior to HIV infection. IL-15 concentrations were associated with a decreased risk of HIV transmission in unadjusted analysis and after adjusting for milk viral load, CD4 cell count, and other cytokines in breast milk. IL-15-mediated immunity may protect against HIV transmission during breast-feeding.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Feeding
/
HIV Infections
/
Infectious Disease Transmission, Vertical
/
Interleukin-15
/
Milk, Human
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Infant
/
Newborn
Language:
En
Journal:
J Infect Dis
Year:
2009
Type:
Article
Affiliation country:
United States