Involvement of the calcium-sensing receptor in human taste perception.
J Biol Chem
; 285(2): 1016-22, 2010 Jan 08.
Article
in En
| MEDLINE
| ID: mdl-19892707
ABSTRACT
By human sensory analyses, we found that various extracellular calcium-sensing receptor (CaSR) agonists enhance sweet, salty, and umami tastes, although they have no taste themselves. These characteristics are known as "kokumi taste" and often appear in traditional Japanese cuisine. Although GSH is a typical kokumi taste substance (taste enhancer), its mode of action is poorly understood. Here, we demonstrate how the kokumi taste is enhanced by the CaSR, a close relative of the class C G-protein-coupled receptors T1R1, T1R2, and T1R3 (sweet and umami receptors). We identified a large number of CaSR agonist gamma-glutamyl peptides, including GSH (gamma-Glu-Cys-Gly) and gamma-Glu-Val-Gly, and showed that these peptides elicit the kokumi taste. Further analyses revealed that some known CaSR agonists such as Ca(2+), protamine, polylysine, L-histidine, and cinacalcet (a calcium-mimetic drug) also elicit the kokumi taste and that the CaSR-specific antagonist, NPS-2143, significantly suppresses the kokumi taste. This is the first report indicating a distinct function of the CaSR in human taste perception.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Taste
/
Receptors, G-Protein-Coupled
/
Receptors, Calcium-Sensing
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
J Biol Chem
Year:
2010
Type:
Article
Affiliation country:
Japan