Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

Wartmann, Thomas; Mayerle, Julia; Kähne, Thilo; Sahin-Tóth, Miklós; Ruthenbürger, Manuel; Matthias, Rainer; Kruse, Anne; Reinheckel, Thomas; Peters, Christoph; Weiss, F Ulrich; Sendler, Matthias; Lippert, Hans; Schulz, Hans-Ulrich; Aghdassi, Ali; Dummer, Annegret; Teller, Steffen; Halangk, Walter; Lerch, Markus M

Wartmann, Thomas; Mayerle, Julia; Kähne, Thilo; Sahin-Tóth, Miklós; Ruthenbürger, Manuel; Matthias, Rainer; Kruse, Anne; Reinheckel, Thomas; Peters, Christoph; Weiss, F Ulrich; Sendler, Matthias; Lippert, Hans; Schulz, Hans-Ulrich; Aghdassi, Ali; Dummer, Annegret; Teller, Steffen; Halangk, Walter; Lerch, Markus M.

Affiliation

Wartmann T; Division of Experimental Surgery, Department of Surgery, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany.

Gastroenterology ; 138(2): 726-37, 2010 Feb.

Article in En | MEDLINE | ID: mdl-19900452

Subject(s)

Cathepsin L/metabolism; Pancreatitis/metabolism; Severity of Illness Index; Trypsinogen/metabolism; Amylases/metabolism; Animals; Apoptosis; Cathepsin B/genetics; Cathepsin B/metabolism; Cathepsin L/genetics; Ceruletide/adverse effects; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Lipase/metabolism; Mice; Mice, Knockout; Pancreatitis/chemically induced; Pancreatitis/pathology; Taurocholic Acid/adverse effects; Trypsin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatitis / Trypsinogen / Severity of Illness Index / Cathepsin L Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2010 Type: Article Affiliation country: Germany

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