Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

Long, Jonathan Z; Nomura, Daniel K; Vann, Robert E; Walentiny, D Matthew; Booker, Lamont; Jin, Xin; Burston, James J; Sim-Selley, Laura J; Lichtman, Aron H; Wiley, Jenny L; Cravatt, Benjamin F

Long, Jonathan Z; Nomura, Daniel K; Vann, Robert E; Walentiny, D Matthew; Booker, Lamont; Jin, Xin; Burston, James J; Sim-Selley, Laura J; Lichtman, Aron H; Wiley, Jenny L; Cravatt, Benjamin F.

Affiliation

Long JZ; The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Proc Natl Acad Sci U S A ; 106(48): 20270-5, 2009 Dec 01.

Article in En | MEDLINE | ID: mdl-19918051

Subject(s)

Amidohydrolases/metabolism; Cannabinoid Receptor Modulators/metabolism; Carbamates/pharmacology; Endocannabinoids; Monoacylglycerol Lipases/metabolism; Piperazines/pharmacology; Piperidines/pharmacology; Amidohydrolases/antagonists & inhibitors; Animals; Arachidonic Acids/metabolism; Carbamates/chemical synthesis; Carboxylic Ester Hydrolases/metabolism; Glycerides/metabolism; Mice; Molecular Structure; Monoacylglycerol Lipases/antagonists & inhibitors; Motor Activity/drug effects; Pain Measurement; Piperazines/chemical synthesis; Piperidines/chemical synthesis; Polyunsaturated Alkamides/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Piperidines / Carbamates / Endocannabinoids / Cannabinoid Receptor Modulators / Amidohydrolases / Monoacylglycerol Lipases Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2009 Type: Article Affiliation country: United States

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