Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.

Basso, Manuela; Samengo, Giuseppina; Nardo, Giovanni; Massignan, Tania; D'Alessandro, Giuseppina; Tartari, Silvia; Cantoni, Lavinia; Marino, Marianna; Cheroni, Cristina; De Biasi, Silvia; Giordana, Maria Teresa; Strong, Michael J; Estevez, Alvaro G; Salmona, Mario; Bendotti, Caterina; Bonetto, Valentina

Basso, Manuela; Samengo, Giuseppina; Nardo, Giovanni; Massignan, Tania; D'Alessandro, Giuseppina; Tartari, Silvia; Cantoni, Lavinia; Marino, Marianna; Cheroni, Cristina; De Biasi, Silvia; Giordana, Maria Teresa; Strong, Michael J; Estevez, Alvaro G; Salmona, Mario; Bendotti, Caterina; Bonetto, Valentina.

Affiliation

Basso M; Dulbecco Telethon Institute, Milan, Italy.

PLoS One ; 4(12): e8130, 2009 Dec 02.

Article in En | MEDLINE | ID: mdl-19956584

Subject(s)

Amyotrophic Lateral Sclerosis/pathology; Detergents/pharmacology; Proteins/chemistry; Proteins/metabolism; Stress, Physiological/drug effects; Tyrosine/analogs & derivatives; Aconitate Hydratase/metabolism; Aconitate Hydratase/ultrastructure; Amino Acid Substitution/genetics; Amyotrophic Lateral Sclerosis/enzymology; Animals; Disease Models, Animal; Disease Progression; Electrophoresis, Gel, Two-Dimensional; Humans; Immunohistochemistry; Mice; NG-Nitroarginine Methyl Ester/pharmacology; Protein Structure, Quaternary; Proteomics; Reproducibility of Results; Solubility/drug effects; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spinal Cord/drug effects; Spinal Cord/ultrastructure; Superoxide Dismutase/metabolism; Superoxide Dismutase-1; Tyrosine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Tyrosine / Proteins / Detergents / Amyotrophic Lateral Sclerosis Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2009 Type: Article Affiliation country: Italy

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