Does gender-specific BMI development modulate insulin sensitivity in extremely low birth weight infants?
J Pediatr Endocrinol Metab
; 22(9): 827-35, 2009 Sep.
Article
in En
| MEDLINE
| ID: mdl-19960892
ABSTRACT
BACKGROUND:
Increasing numbers of extremely low birth weight infants (ELBW, birth weight < 1,000 g) survive. We studied the impact of birth weight, gender, and catch-up growth on metabolic parameters in ELBW infants. CHILDREN Sixty-three ELBW children were investigated at a mean age of 5.8 years. Forty-eight showed catch-up growth.RESULTS:
ELBW children who were small for gestational age were significantly shorter than those whose size was appropriate for their gestational age (height SDS -1.1 [SD 0.8] vs -0.4 [0.9]; p < 0.001). This corresponded with significantly lower standard deviation scores for IGF-I (-1.1 [1.3] vs 0.1 [0.8]; p < 0.05) and IGFBP-3 (-0.7 [1.7] vs 0.4 [1.1]; p < 0.05). No differences were found regarding fasting insulin, glucose, HOMA and IGFBP-1. The catch-up group showed lower IGFBP-1 concentrations than the non-catch-up group. IGFBP-1 decreased in individuals who became more insulin resistant. No differences were found regarding mean IGF-1 and IGFBP-3 SDS. A gender-related pattern was found for weight development girls demonstrated a normalization of BMI from the age of 2 years whereas boys remained at a mean BMI of -1.96 SDS. Corresponding to this, girls showed lower IGFBP-1 levels than boys.CONCLUSION:
Metabolic parameters in ELBW children are modulated by subsequent catch-up growth and sex-dependent weight development, resulting in measurable differences even in early childhood.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Body Mass Index
/
Sex Characteristics
/
Infant, Extremely Low Birth Weight
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
J Pediatr Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
PEDIATRIA
Year:
2009
Type:
Article
Affiliation country:
Germany