Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.

Koitabashi, Norimichi; Aiba, Takeshi; Hesketh, Geoffrey G; Rowell, Janelle; Zhang, Manling; Takimoto, Eiki; Tomaselli, Gordon F; Kass, David A

Koitabashi, Norimichi; Aiba, Takeshi; Hesketh, Geoffrey G; Rowell, Janelle; Zhang, Manling; Takimoto, Eiki; Tomaselli, Gordon F; Kass, David A.

Affiliation

Koitabashi N; Division of Cardiology, Ross 858, Department of Medicine, Johns Hopkins University Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA.

J Mol Cell Cardiol ; 48(4): 713-24, 2010 Apr.

Article in En | MEDLINE | ID: mdl-19961855

Subject(s)

Cyclic GMP-Dependent Protein Kinases/metabolism; Gene Expression Regulation; NFATC Transcription Factors/metabolism; Phosphodiesterase 5 Inhibitors; TRPC Cation Channels/metabolism; Angiotensins/biosynthesis; Animals; Aorta/pathology; Endothelins/biosynthesis; Humans; Mice; Mice, Inbred C57BL; Muscle Cells/cytology; Mutation; Myocytes, Cardiac/cytology; Phosphorylation; Piperazines/pharmacology; Purines/pharmacology; Rats; Sildenafil Citrate; Sulfones/pharmacology; TRPC6 Cation Channel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Cyclic GMP-Dependent Protein Kinases / TRPC Cation Channels / NFATC Transcription Factors / Phosphodiesterase 5 Inhibitors Limits: Animals / Humans Language: En Journal: J Mol Cell Cardiol Year: 2010 Type: Article Affiliation country: United States

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