Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus.

Warn, Peter A; Sharp, Andrew; Morrissey, Graham; Denning, David W

Warn, Peter A; Sharp, Andrew; Morrissey, Graham; Denning, David W.

Affiliation

Warn PA; School of Translational Medicine, The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PT, UK. peter.warn@manchester.ac.uk

Int J Antimicrob Agents ; 35(2): 146-51, 2010 Feb.

Article in En | MEDLINE | ID: mdl-20015618

Subject(s)

Antifungal Agents/therapeutic use; Aspergillosis/drug therapy; Aspergillus fumigatus/drug effects; Administration, Oral; Amphotericin B/administration & dosage; Amphotericin B/therapeutic use; Animals; Antifungal Agents/administration & dosage; Aspergillus fumigatus/isolation & purification; Caspofungin; Colony Count, Microbial; Disease Models, Animal; Echinocandins/administration & dosage; Echinocandins/therapeutic use; Injections, Intraperitoneal; Injections, Intravenous; Itraconazole/administration & dosage; Itraconazole/therapeutic use; Kidney/microbiology; Lipopeptides/administration & dosage; Lipopeptides/therapeutic use; Liver/microbiology; Male; Micafungin; Mice; Survival Analysis; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aspergillosis / Aspergillus fumigatus / Antifungal Agents Limits: Animals Language: En Journal: Int J Antimicrob Agents Year: 2010 Type: Article Affiliation country: United kingdom

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