Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.

Fernandez, Karen; Serinagaoglu, Yelda; Hammond, Sue; Martin, Laura T; Martin, Paul T

Fernandez, Karen; Serinagaoglu, Yelda; Hammond, Sue; Martin, Laura T; Martin, Paul T.

Affiliation

Fernandez K; Division of Hematology/Oncology, Nationwide Children's Hospital, Columbus, Ohio 43205, USA.

Am J Pathol ; 176(1): 416-34, 2010 Jan.

Article in En | MEDLINE | ID: mdl-20019182

Subject(s)

Alternative Splicing/genetics; Dystrophin/deficiency; Mutation/genetics; Proto-Oncogene Proteins c-mdm2/genetics; Rhabdomyosarcoma, Embryonal/pathology; Sarcoglycans/deficiency; Tumor Suppressor Protein p53/genetics; Aging/pathology; Animals; Cell Death; Dystrophin/metabolism; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Mice; Muscle, Skeletal/metabolism; Muscle, Skeletal/pathology; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Precancerous Conditions/genetics; Precancerous Conditions/pathology; Proto-Oncogene Proteins c-mdm2/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rhabdomyosarcoma, Alveolar/genetics; Rhabdomyosarcoma, Alveolar/pathology; Rhabdomyosarcoma, Embryonal/genetics; Sarcoglycans/metabolism; Tissue Array Analysis; Tumor Suppressor Protein p53/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dystrophin / Tumor Suppressor Protein p53 / Alternative Splicing / Rhabdomyosarcoma, Embryonal / Sarcoglycans / Proto-Oncogene Proteins c-mdm2 / Mutation Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2010 Type: Article Affiliation country: United States

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