Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats.

Minor, Robin K; Smith, Daniel L; Sossong, Alex M; Kaushik, Susmita; Poosala, Suresh; Spangler, Edward L; Roth, George S; Lane, Mark; Allison, David B; de Cabo, Rafael; Ingram, Donald K; Mattison, Julie A

Minor, Robin K; Smith, Daniel L; Sossong, Alex M; Kaushik, Susmita; Poosala, Suresh; Spangler, Edward L; Roth, George S; Lane, Mark; Allison, David B; de Cabo, Rafael; Ingram, Donald K; Mattison, Julie A.

Affiliation

Minor RK; Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Toxicol Appl Pharmacol ; 243(3): 332-9, 2010 Mar 15.

Article in En | MEDLINE | ID: mdl-20026095

Subject(s)

Deoxyglucose/pharmacology; Deoxyglucose/toxicity; Heart/drug effects; Myocardium/ultrastructure; Vacuoles/drug effects; Adrenal Glands/drug effects; Adrenal Glands/pathology; Animals; Autophagy/drug effects; Blotting, Western; Body Temperature/drug effects; Body Weight/drug effects; Glucose/metabolism; Glycogen/metabolism; Insulin/metabolism; Lipid Metabolism/drug effects; Male; Myocardium/pathology; Rats; Rats, Inbred BN; Rats, Inbred F344; Survival Analysis; Vacuoles/ultrastructure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vacuoles / Deoxyglucose / Heart / Myocardium Type of study: Observational_studies / Prognostic_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2010 Type: Article Affiliation country: United States

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