Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Le Cras, Timothy D; Korfhagen, Thomas R; Davidson, Cynthia; Schmidt, Stephanie; Fenchel, Matthew; Ikegami, Machiko; Whitsett, Jeffrey A; Hardie, William D

Le Cras, Timothy D; Korfhagen, Thomas R; Davidson, Cynthia; Schmidt, Stephanie; Fenchel, Matthew; Ikegami, Machiko; Whitsett, Jeffrey A; Hardie, William D.

Affiliation

Le Cras TD; Divisions of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Am J Pathol ; 176(2): 679-86, 2010 Feb.

Article in En | MEDLINE | ID: mdl-20042669

Subject(s)

Gonanes/pharmacology; Gonanes/therapeutic use; Phosphoinositide-3 Kinase Inhibitors; Pulmonary Fibrosis/chemically induced; Pulmonary Fibrosis/prevention & control; Transforming Growth Factor alpha; Administration, Oral; Animals; Disease Progression; Drug Evaluation, Preclinical; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Gonanes/administration & dosage; Mice; Mice, Transgenic; Oncogene Protein v-akt/metabolism; Phosphorylation/drug effects; Uteroglobin/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Transforming Growth Factor alpha / Phosphoinositide-3 Kinase Inhibitors / Gonanes Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Pathol Year: 2010 Type: Article Affiliation country: United States

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