RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis.

Kim, Min Seuk; Yang, Yu-Mi; Son, Aran; Tian, Yu Shun; Lee, Syng-Ill; Kang, Sang Won; Muallem, Shmuel; Shin, Dong Min

Kim, Min Seuk; Yang, Yu-Mi; Son, Aran; Tian, Yu Shun; Lee, Syng-Ill; Kang, Sang Won; Muallem, Shmuel; Shin, Dong Min.

Affiliation

Kim MS; Department of Oral Biology, Brain Korea 21 Project, Oral Science Research Center, Center for Natural Defense System, Yonsei University College of Dentistry, Seoul 120-752, Korea.

J Biol Chem ; 285(10): 6913-21, 2010 Mar 05.

Article in En | MEDLINE | ID: mdl-20048168

Subject(s)

Calcium Signaling/physiology; Cell Differentiation/physiology; Osteoclasts/physiology; RANK Ligand/metabolism; Reactive Oxygen Species/metabolism; Animals; Bone Marrow Cells/cytology; Bone Marrow Cells/physiology; Bone and Bones/anatomy & histology; Bone and Bones/physiology; Cells, Cultured; Macrophages/cytology; Macrophages/physiology; Mice; Mice, Knockout; Osteoclasts/cytology; Osteogenesis/physiology; Peroxiredoxins/genetics; Peroxiredoxins/metabolism; Phospholipase C gamma/antagonists & inhibitors; Phospholipase C gamma/metabolism; RNA Interference; Signal Transduction/physiology; rac1 GTP-Binding Protein/genetics; rac1 GTP-Binding Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Cell Differentiation / Reactive Oxygen Species / Calcium Signaling / RANK Ligand Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2010 Type: Article

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