Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease.

Yang, Zhong; Zhang, Yingge; Yang, Yanlian; Sun, Lan; Han, Dong; Li, Hong; Wang, Chen

Yang, Zhong; Zhang, Yingge; Yang, Yanlian; Sun, Lan; Han, Dong; Li, Hong; Wang, Chen.

Affiliation

Yang Z; Key Laboratory of Nanopharmacology and Nanotoxicology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.

Nanomedicine ; 6(3): 427-41, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20056170

Subject(s)

Alzheimer Disease/drug therapy; Drug Carriers/adverse effects; Drug Carriers/toxicity; Lysosomes/metabolism; Mitochondria/metabolism; Nanomedicine/methods; Nanotubes, Carbon/adverse effects; Nanotubes, Carbon/toxicity; Acetylcholine/administration & dosage; Acetylcholine/pharmacology; Alzheimer Disease/pathology; Alzheimer Disease/physiopathology; Animals; Autophagy/drug effects; Brain/drug effects; Brain/pathology; Brain/ultrastructure; Cell Survival/drug effects; Drug Carriers/pharmacokinetics; Health Status; Intestinal Absorption/drug effects; Lysosomes/drug effects; Lysosomes/ultrastructure; Memory/drug effects; Mice; Mitochondria/drug effects; Mitochondria/ultrastructure; Nanotubes, Carbon/ultrastructure; Organ Specificity/drug effects; Reproducibility of Results; Spectrum Analysis, Raman; Subcellular Fractions/drug effects; Subcellular Fractions/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Carriers / Nanotubes, Carbon / Nanomedicine / Alzheimer Disease / Lysosomes / Mitochondria Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nanomedicine Journal subject: BIOTECNOLOGIA Year: 2010 Type: Article Affiliation country: China

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