Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography.

Gug, Fabienne; Oumata, Nassima; Tribouillard-Tanvier, Déborah; Voisset, Cécile; Desban, Nathalie; Bach, Stéphane; Blondel, Marc; Galons, Hervé

Gug, Fabienne; Oumata, Nassima; Tribouillard-Tanvier, Déborah; Voisset, Cécile; Desban, Nathalie; Bach, Stéphane; Blondel, Marc; Galons, Hervé.

Affiliation

Gug F; Laboratoire de Chimie Organique 2, INSERM U648, Universite Paris-Descartes, 4 avenue de l'Observatoire, 75270 Paris cedex 06, France.

Bioconjug Chem ; 21(2): 279-88, 2010 Feb 17.

Article in En | MEDLINE | ID: mdl-20092293

Subject(s)

Chromatography, Affinity; Guanabenz/chemical synthesis; Guanabenz/metabolism; Phenanthridines/chemical synthesis; Phenanthridines/metabolism; Prions/antagonists & inhibitors; Binding, Competitive; Chlorpromazine/metabolism; Guanabenz/chemistry; Guanabenz/pharmacology; Microspheres; Phenanthridines/chemistry; Phenanthridines/pharmacology; Quinacrine/metabolism; RNA, Ribosomal/metabolism; Ribosomes/metabolism; Sepharose/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenanthridines / Prions / Chromatography, Affinity / Guanabenz Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2010 Type: Article Affiliation country: France

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