Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors.

Koblish, Holly K; Hansbury, Michael J; Bowman, Kevin J; Yang, Gengjie; Neilan, Claire L; Haley, Patrick J; Burn, Timothy C; Waeltz, Paul; Sparks, Richard B; Yue, Eddy W; Combs, Andrew P; Scherle, Peggy A; Vaddi, Kris; Fridman, Jordan S

Koblish, Holly K; Hansbury, Michael J; Bowman, Kevin J; Yang, Gengjie; Neilan, Claire L; Haley, Patrick J; Burn, Timothy C; Waeltz, Paul; Sparks, Richard B; Yue, Eddy W; Combs, Andrew P; Scherle, Peggy A; Vaddi, Kris; Fridman, Jordan S.

Affiliation

Koblish HK; Preclinical Biology, Incyte Corporation, Experimental Station, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA. hkoblish@incyte.com

Mol Cancer Ther ; 9(2): 489-98, 2010 Feb.

Article in En | MEDLINE | ID: mdl-20124451

Subject(s)

Amidines/pharmacology; Enzyme Inhibitors/pharmacology; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism; Neoplasms/metabolism; Tryptophan/metabolism; Animals; Cell Line, Tumor; Dogs; Female; Humans; Immune System; Immunotherapy/methods; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors; Kynurenine/pharmacology; Lymph Nodes/pathology; Lymphocytes/immunology; Mice; Mice, Inbred BALB C; Neoplasms/drug therapy; Neoplasms/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Enzyme Inhibitors / Indoleamine-Pyrrole 2,3,-Dioxygenase / Amidines / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2010 Type: Article Affiliation country: United States

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