3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators.

Bernotas, Ronald C; Antane, Schuyler; Shenoy, Rajesh; Le, Van-Duc; Chen, Ping; Harrison, Boyd L; Robichaud, Albert J; Zhang, Guo Ming; Smith, Deborah; Schechter, Lee E

Bernotas, Ronald C; Antane, Schuyler; Shenoy, Rajesh; Le, Van-Duc; Chen, Ping; Harrison, Boyd L; Robichaud, Albert J; Zhang, Guo Ming; Smith, Deborah; Schechter, Lee E.

Affiliation

Bernotas RC; Chemical Sciences, Wyeth Pharmaceuticals, 500 Arcola Road, Collegeville, PA 19426, USA. bernotr@wyeth.com

Bioorg Med Chem Lett ; 20(5): 1657-60, 2010 Mar 01.

Article in En | MEDLINE | ID: mdl-20138763

Subject(s)

Indoles/chemistry; Receptors, Serotonin/chemistry; Serotonin Antagonists/chemistry; Serotonin Receptor Agonists/chemistry; Sulfones/chemistry; Humans; Indoles/chemical synthesis; Indoles/pharmacology; Ligands; Receptors, Serotonin/metabolism; Serotonin Antagonists/chemical synthesis; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/chemical synthesis; Serotonin Receptor Agonists/pharmacology; Structure-Activity Relationship; Sulfones/chemical synthesis; Sulfones/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serotonin Antagonists / Sulfones / Receptors, Serotonin / Serotonin Receptor Agonists / Indoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United States

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