Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia.

Kato, T; Abe, Y; Sotoyama, H; Kakita, A; Kominami, R; Hirokawa, S; Ozaki, M; Takahashi, H; Nawa, H

Kato, T; Abe, Y; Sotoyama, H; Kakita, A; Kominami, R; Hirokawa, S; Ozaki, M; Takahashi, H; Nawa, H.

Affiliation

Kato T; Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.

Mol Psychiatry ; 16(3): 307-20, 2011 Mar.

Article in En | MEDLINE | ID: mdl-20142818

Subject(s)

Brain; Dopamine/metabolism; Gene Expression Regulation, Developmental/drug effects; Neuregulin-1/pharmacology; Acoustic Stimulation; Animals; Animals, Newborn; Behavior, Animal/drug effects; Biotinylation; Brain/drug effects; Brain/growth & development; Brain/metabolism; Dopamine Antagonists/pharmacology; Dose-Response Relationship, Drug; Hearing/drug effects; Immunoprecipitation; Levodopa/metabolism; Locomotion/drug effects; Methamphetamine/pharmacology; Mice; Microdialysis/methods; Phosphorylation/drug effects; Potassium/pharmacology; Proto-Oncogene Proteins c-fos/metabolism; Reflex, Startle/drug effects; Risperidone/pharmacology; Social Behavior; Statistics, Nonparametric; Tyrosine 3-Monooxygenase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Dopamine / Gene Expression Regulation, Developmental / Neuregulin-1 Limits: Animals Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2011 Type: Article Affiliation country: Japan

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