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Synthesis of a quinolone library from ynones.
Ward, Timothy R; Turunen, Brandon J; Haack, Torsten; Neuenswander, Benjamin; Shadrick, William; Georg, Gunda I.
Affiliation
  • Ward TR; Department of Medicinal Chemistry and Center for Methodology and Library Development, University of Kansas, 1251 Wescoe Hall Drive, Lawrence Kansas 66045, USA; Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, USA.
Tetrahedron Lett ; 50(47): 6494-9497, 2009 Nov 25.
Article in En | MEDLINE | ID: mdl-20161410
ABSTRACT
A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked ß-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Tetrahedron Lett Year: 2009 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Tetrahedron Lett Year: 2009 Type: Article Affiliation country: United States