Cdk2 is required for p53-independent G2/M checkpoint control.

Chung, Jon H; Bunz, Fred

Chung, Jon H; Bunz, Fred.

Affiliation

Chung JH; Department of Radiation Oncology and Molecular Radiation Sciences and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

PLoS Genet ; 6(2): e1000863, 2010 Feb 26.

Article in En | MEDLINE | ID: mdl-20195506

Subject(s)

Cyclin-Dependent Kinase 2/metabolism; G2 Phase; Mitosis; Tumor Suppressor Protein p53/metabolism; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins/metabolism; Checkpoint Kinase 1; Cyclin-Dependent Kinase 2/deficiency; Cytoplasm/metabolism; Cytoplasm/radiation effects; Enzyme Activation/radiation effects; Enzyme Stability/radiation effects; G2 Phase/radiation effects; HCT116 Cells; Humans; Mice; Mitosis/radiation effects; Models, Biological; Nuclear Proteins/metabolism; Phosphorylation/radiation effects; Protein Kinases/metabolism; Protein Processing, Post-Translational/radiation effects; Protein Serine-Threonine Kinases/metabolism; Protein Transport/radiation effects; Radiation, Ionizing; cdc25 Phosphatases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: G2 Phase / Tumor Suppressor Protein p53 / Cyclin-Dependent Kinase 2 / Mitosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2010 Type: Article Affiliation country: United States

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