Growth differentiation factor 15 acts anti-apoptotic and pro-hypertrophic in adult cardiomyocytes.

Heger, J; Schiegnitz, E; von Waldthausen, D; Anwar, M M; Piper, H M; Euler, G

Heger, J; Schiegnitz, E; von Waldthausen, D; Anwar, M M; Piper, H M; Euler, G.

Affiliation

Heger J; Physiologisches Institut, Justus-Liebig-Universität Giessen, Giessen, Germany.

J Cell Physiol ; 224(1): 120-6, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20232299

Subject(s)

Apoptosis; Cardiomegaly/metabolism; Cardiomegaly/pathology; Growth Differentiation Factor 15/metabolism; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Signal Transduction; Age Factors; Angiotensin II/metabolism; Animals; Apoptosis/drug effects; Cardiomegaly/prevention & control; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases/metabolism; Male; Myocytes, Cardiac/drug effects; Nitric Oxide Donors/pharmacology; Oligonucleotides/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors/pharmacology; Rats; Rats, Wistar; Signal Transduction/drug effects; Smad1 Protein/genetics; Smad1 Protein/metabolism; Time Factors; Transforming Growth Factor beta1/metabolism; Ventricular Remodeling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Apoptosis / Cardiomegaly / Myocytes, Cardiac / Growth Differentiation Factor 15 Limits: Animals Language: En Journal: J Cell Physiol Year: 2010 Type: Article Affiliation country: Germany

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