Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation.

Lochhead, Jeffrey J; McCaffrey, Gwen; Quigley, Colleen E; Finch, Jessica; DeMarco, Kristin M; Nametz, Nicole; Davis, Thomas P

Lochhead, Jeffrey J; McCaffrey, Gwen; Quigley, Colleen E; Finch, Jessica; DeMarco, Kristin M; Nametz, Nicole; Davis, Thomas P.

Affiliation

Lochhead JJ; Program in Neuroscience, University of Arizona College of Medicine, Tucson, Arizona 85724, USA.

J Cereb Blood Flow Metab ; 30(9): 1625-36, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20234382

Subject(s)

Blood-Brain Barrier/physiology; Hypoxia, Brain/metabolism; Membrane Proteins/metabolism; Oxidative Stress/physiology; Animals; Blotting, Western; Capillaries/metabolism; Capillaries/physiology; Centrifugation, Density Gradient; Cerebrovascular Circulation/physiology; Cyclic N-Oxides/pharmacology; Electrophoresis, Polyacrylamide Gel; Female; Fluorescent Antibody Technique; Free Radical Scavengers/pharmacology; HSP70 Heat-Shock Proteins/biosynthesis; Hypoxia, Brain/pathology; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Indicators and Reagents; Microscopy, Confocal; Occludin; Permeability; Rats; Rats, Sprague-Dawley; Spin Labels; Translocation, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Hypoxia, Brain / Oxidative Stress / Membrane Proteins Limits: Animals Language: En Journal: J Cereb Blood Flow Metab Year: 2010 Type: Article Affiliation country: United States

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