Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.

Bonifazi, Evelyn L; Ríos-Luci, Carla; León, Leticia G; Burton, Gerardo; Padrón, José M; Misico, Rosana I

Bonifazi, Evelyn L; Ríos-Luci, Carla; León, Leticia G; Burton, Gerardo; Padrón, José M; Misico, Rosana I.

Affiliation

Bonifazi EL; Departamento de Química Orgánica and UMYMFOR (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

Bioorg Med Chem ; 18(7): 2621-30, 2010 Apr 01.

Article in En | MEDLINE | ID: mdl-20304655

Subject(s)

Antineoplastic Agents, Phytogenic/chemical synthesis; Antineoplastic Agents, Phytogenic/pharmacology; Naphthoquinones/chemistry; Naphthoquinones/chemical synthesis; Naphthoquinones/pharmacology; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Lipids/chemistry; Magnetic Resonance Spectroscopy; Prenylation; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Naphthoquinones / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: Argentina

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