Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex.

Cotella, Diego; Radicke, Susanne; Bortoluzzi, Alessio; Ravens, Ursula; Wettwer, Erich; Santoro, Claudio; Sblattero, Daniele

Cotella, Diego; Radicke, Susanne; Bortoluzzi, Alessio; Ravens, Ursula; Wettwer, Erich; Santoro, Claudio; Sblattero, Daniele.

Affiliation

Cotella D; Department of Medical Sciences and Interdisciplinary Research Center for Autoimmune Diseases (IRCAD), University of Eastern Piedmont "A. Avogadro", Via Solaroli 17, Novara, 28100, Italy. diego.cotella@med.unipmn.it

Pflugers Arch ; 460(1): 87-97, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20354865

Subject(s)

Cell Membrane/metabolism; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/metabolism; Ion Channel Gating; Kv Channel-Interacting Proteins/metabolism; Potassium/metabolism; Protein Processing, Post-Translational; Shal Potassium Channels/metabolism; Animals; CHO Cells; Cell Membrane/drug effects; Cricetinae; Cricetulus; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/genetics; Glycosylation; Heart Atria/metabolism; Humans; Ion Channel Gating/drug effects; Kinetics; Kv Channel-Interacting Proteins/genetics; Membrane Potentials; Myocytes, Cardiac/metabolism; Neuraminidase/pharmacology; Protein Processing, Post-Translational/drug effects; Protein Transport; Shal Potassium Channels/drug effects; Shal Potassium Channels/genetics; Transfection; Tunicamycin/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Ion Channel Gating / Cell Membrane / Protein Processing, Post-Translational / Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Kv Channel-Interacting Proteins / Shal Potassium Channels Limits: Animals / Humans Language: En Journal: Pflugers Arch Year: 2010 Type: Article Affiliation country: Italy

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