Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease.

Janssens, Wim; Nuytten, Hilde; Dupont, Lieven J; Van Eldere, Johan; Vermeire, Severine; Lambrechts, Diether; Nackaerts, Kristiaan; Decramer, Marc; Cassiman, Jean-Jacques; Cuppens, Harry

Janssens, Wim; Nuytten, Hilde; Dupont, Lieven J; Van Eldere, Johan; Vermeire, Severine; Lambrechts, Diether; Nackaerts, Kristiaan; Decramer, Marc; Cassiman, Jean-Jacques; Cuppens, Harry.

Affiliation

Janssens W; Department of Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O&N1 (602), Herestraat 49, B-3000, Leuven, Belgium.

Am J Respir Crit Care Med ; 182(2): 163-9, 2010 Jul 15.

Article in En | MEDLINE | ID: mdl-20378733

Subject(s)

Epithelial Cells/metabolism; Gene Dosage; Genetic Variation; Pulmonary Disease, Chronic Obstructive/genetics; beta-Defensins/genetics; Aged; Case-Control Studies; Cells, Cultured; Diploidy; Female; Genetic Predisposition to Disease; Humans; Interleukin-8/metabolism; Male; Middle Aged; Nasal Mucosa/cytology; Polymerase Chain Reaction; Pseudomonas aeruginosa; RNA, Messenger/metabolism; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Variation / Gene Dosage / Beta-Defensins / Pulmonary Disease, Chronic Obstructive / Epithelial Cells Type of study: Observational_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Am J Respir Crit Care Med Journal subject: TERAPIA INTENSIVA Year: 2010 Type: Article Affiliation country: Belgium

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