Can changes in cortical excitability distinguish progressive from juvenile myoclonic epilepsy?
Epilepsia
; 51(10): 2084-8, 2010 Oct.
Article
in En
| MEDLINE
| ID: mdl-20384725
ABSTRACT
PURPOSE:
We used transcranial magnetic stimulation (TMS) to investigate whether there were any characteristic cortical excitability changes in progressive myoclonic epilepsy (PME) compared to juvenile myoclonic epilepsy (JME).METHODS:
Six patients with PME were studied. Motor threshold (MT) at rest and recovery curve analysis using paired-pulse stimulation at a number of interstimulus intervals (ISIs) was determined. Results were compared to those of 9 patients with chronic refractory JME and 10 with chronic well-controlled JME.RESULTS:
PME showed a marked increase in cortical excitability at all the long ISIs (p < 0.01), compared to refractory JME (effect sizes ranging from 1.4 to 1.9) and well-controlled JME (effect sizes ranging from 2.0 to 2.4). Significant differences at the short ISIs 2-5 ms were seen only on comparison with the well-controlled group (p < 0.05, effect size 0.6, 0.7). There were no significant differences in MTs of PME compared to either JME groups.CONCLUSION:
Our findings demonstrate specific differences in cortical excitability using TMS between PME and those with JME, particularly at long latencies in the paired-pulse paradigm, implicating a role for γ-aminobutyric acid (GABA)(B) -mediated networks.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myoclonic Epilepsy, Juvenile
/
Myoclonic Epilepsies, Progressive
/
Transcranial Magnetic Stimulation
/
Motor Cortex
Type of study:
Diagnostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Epilepsia
Year:
2010
Type:
Article
Affiliation country:
Australia