Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory.

Martin, Loren J; Zurek, Agnieszka A; MacDonald, John F; Roder, John C; Jackson, Michael F; Orser, Beverley A

Martin, Loren J; Zurek, Agnieszka A; MacDonald, John F; Roder, John C; Jackson, Michael F; Orser, Beverley A.

Affiliation

Martin LJ; Department of Physiology, Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada. ljmartin@bu.edu

J Neurosci ; 30(15): 5269-82, 2010 Apr 14.

Article in En | MEDLINE | ID: mdl-20392949

Subject(s)

Hippocampus/physiology; Long-Term Potentiation/physiology; Memory/physiology; Receptors, GABA-A/metabolism; Animals; Association Learning; CA1 Region, Hippocampal/drug effects; CA1 Region, Hippocampal/physiology; Electric Impedance; Electric Stimulation/methods; Fear; GABA-A Receptor Antagonists; Hippocampus/drug effects; In Vitro Techniques; Long-Term Potentiation/drug effects; Male; Membrane Potentials/drug effects; Membrane Potentials/physiology; Memory/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition/drug effects; Neural Inhibition/physiology; Patch-Clamp Techniques; Pyramidal Cells/drug effects; Pyramidal Cells/physiology; Receptors, GABA-A/genetics; Receptors, Glutamate/metabolism; Synaptic Transmission/drug effects; Synaptic Transmission/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long-Term Potentiation / Receptors, GABA-A / Hippocampus / Memory Limits: Animals Language: En Journal: J Neurosci Year: 2010 Type: Article Affiliation country: Canada

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