Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.

Oliver, Trudy G; Mercer, Kim L; Sayles, Leanne C; Burke, James R; Mendus, Diana; Lovejoy, Katherine S; Cheng, Mei-Hsin; Subramanian, Aravind; Mu, David; Powers, Scott; Crowley, Denise; Bronson, Roderick T; Whittaker, Charles A; Bhutkar, Arjun; Lippard, Stephen J; Golub, Todd; Thomale, Juergen; Jacks, Tyler; Sweet-Cordero, E Alejandro

Oliver, Trudy G; Mercer, Kim L; Sayles, Leanne C; Burke, James R; Mendus, Diana; Lovejoy, Katherine S; Cheng, Mei-Hsin; Subramanian, Aravind; Mu, David; Powers, Scott; Crowley, Denise; Bronson, Roderick T; Whittaker, Charles A; Bhutkar, Arjun; Lippard, Stephen J; Golub, Todd; Thomale, Juergen; Jacks, Tyler; Sweet-Cordero, E Alejandro.

Affiliation

Oliver TG; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, 02139, USA.

Genes Dev ; 24(8): 837-52, 2010 Apr 15.

Article in En | MEDLINE | ID: mdl-20395368

Subject(s)

Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Carcinoma, Non-Small-Cell Lung/drug therapy; Cisplatin/pharmacology; Cisplatin/therapeutic use; DNA Repair/drug effects; Lung Neoplasms/drug therapy; Animals; Carcinoma, Non-Small-Cell Lung/pathology; Carrier Proteins/metabolism; Cell Line, Tumor; Death Domain Receptor Signaling Adaptor Proteins; Disease Models, Animal; Drug Resistance, Neoplasm/physiology; Gene Expression Profiling; Humans; Lung Neoplasms/pathology; Mice; Oligonucleotide Array Sequence Analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Carcinoma, Non-Small-Cell Lung / DNA Repair / Lung Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2010 Type: Article Affiliation country: United States

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