Three arginine residues within the RGG box are crucial for ICP27 binding to herpes simplex virus 1 GC-rich sequences and for efficient viral RNA export.

Corbin-Lickfett, Kara A; Souki, Stuart K; Cocco, Melanie J; Sandri-Goldin, Rozanne M

Corbin-Lickfett, Kara A; Souki, Stuart K; Cocco, Melanie J; Sandri-Goldin, Rozanne M.

Affiliation

Corbin-Lickfett KA; Department of Microbiology and Molecular Genetics, School of Medicine, Medical Sciences I, University of California at Irvine, Irvine, CA 92697-4025, USA.

J Virol ; 84(13): 6367-76, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20410270

Subject(s)

GC Rich Sequence; Herpesvirus 1, Human/physiology; Immediate-Early Proteins/metabolism; RNA, Messenger/metabolism; RNA, Viral/metabolism; Virus Replication; Amino Acid Substitution/genetics; Animals; Arginine/genetics; Chlorocebus aethiops; HeLa Cells; Humans; Immediate-Early Proteins/chemistry; Immediate-Early Proteins/genetics; Lysine/genetics; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Tertiary; RNA Transport; Vero Cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Replication / RNA, Messenger / RNA, Viral / Immediate-Early Proteins / Herpesvirus 1, Human / GC Rich Sequence Limits: Animals / Humans Language: En Journal: J Virol Year: 2010 Type: Article Affiliation country: United States

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