Age-associated differences in activation of Akt/GSK-3beta signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart.

Zhu, Jiang; Rebecchi, Mario J; Tan, Minyi; Glass, Peter S A; Brink, Peter R; Liu, Lixin

Zhu, Jiang; Rebecchi, Mario J; Tan, Minyi; Glass, Peter S A; Brink, Peter R; Liu, Lixin.

Affiliation

Zhu J; Department of Anesthesiology, Stony Brook University School of Medicine, HSC L4 060, Stony Brook, NY 11794, USA.

J Gerontol A Biol Sci Med Sci ; 65(6): 611-9, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20427381

Subject(s)

Aging/metabolism; Glycogen Synthase Kinase 3/metabolism; Mitochondrial Membrane Transport Proteins/antagonists & inhibitors; Myocardium/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction; Anesthetics, Inhalation/pharmacology; Animals; Cardiotonic Agents/pharmacology; Glycogen Synthase Kinase 3 beta; Heart Ventricles; Hemodynamics; Ischemic Preconditioning, Myocardial/methods; Isoflurane/pharmacology; Male; Microscopy, Electron; Mitochondria, Heart/drug effects; Mitochondria, Heart/ultrastructure; Mitochondrial Permeability Transition Pore; Myocardial Infarction/pathology; Myocardial Infarction/physiopathology; Myocardial Reperfusion Injury/metabolism; NAD/metabolism; Phosphorylation/drug effects; Rats; Rats, Inbred F344

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Signal Transduction / Glycogen Synthase Kinase 3 / Mitochondrial Membrane Transport Proteins / Proto-Oncogene Proteins c-akt / Myocardium Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Gerontol A Biol Sci Med Sci Journal subject: GERIATRIA Year: 2010 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google