Synthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloid.

Hu, Xiang-Guo; Bartholomew, Barbara; Nash, Robert J; Wilson, Francis X; Fleet, George W J; Nakagawa, Shinpei; Kato, Atsushi; Jia, Yue-Mei; van Well, Renate; Yu, Chu-Yi

Hu, Xiang-Guo; Bartholomew, Barbara; Nash, Robert J; Wilson, Francis X; Fleet, George W J; Nakagawa, Shinpei; Kato, Atsushi; Jia, Yue-Mei; van Well, Renate; Yu, Chu-Yi.

Affiliation

Hu XG; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Org Lett ; 12(11): 2562-5, 2010 Jun 04.

Article in En | MEDLINE | ID: mdl-20438104

Subject(s)

Alkaloids/chemical synthesis; Hexosaminidases/antagonists & inhibitors; Imino Sugars/chemical synthesis; Indolizidines/chemical synthesis; Alkaloids/chemistry; Alkaloids/pharmacology; Imino Sugars/chemistry; Imino Sugars/pharmacology; Indolizidines/chemistry; Indolizidines/pharmacology; Molecular Structure; Stereoisomerism; Stevia/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkaloids / Imino Sugars / Indolizidines / Hexosaminidases Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2010 Type: Article Affiliation country: China

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