The immunosuppressive tumor environment is the major impediment to successful therapeutic vaccination in Neu transgenic mice.

Burgents, Joseph E; Moran, Timothy P; West, Michelle L; Davis, Nancy L; Johnston, Robert E; Serody, Jonathan S

Burgents, Joseph E; Moran, Timothy P; West, Michelle L; Davis, Nancy L; Johnston, Robert E; Serody, Jonathan S.

Affiliation

Burgents JE; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599-7295, USA.

J Immunother ; 33(5): 482-91, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20463599

Subject(s)

Alphavirus/genetics; Autoantigens/immunology; Cancer Vaccines; Immunosuppression Therapy; Receptor, ErbB-2/immunology; Adoptive Transfer; Alphavirus/pathogenicity; Animals; Autoantigens/administration & dosage; Autoantigens/genetics; Autoantigens/metabolism; Cell Proliferation/drug effects; Female; Mice; Mice, Transgenic; Myeloid Cells/immunology; Myeloid Cells/pathology; Rats; Receptor, ErbB-2/administration & dosage; Receptor, ErbB-2/genetics; Receptor, ErbB-2/metabolism; Remission Induction; Self Tolerance/genetics; Self Tolerance/immunology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; T-Lymphocytes/pathology; Tumor Escape

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantigens / Immunosuppression Therapy / Alphavirus / Receptor, ErbB-2 / Cancer Vaccines Limits: Animals Language: En Journal: J Immunother Journal subject: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Year: 2010 Type: Article Affiliation country: United States

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