Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells.

Yang, Zhou; Xiaohua, Wang; Lei, Jiang; Ruoyun, Tan; Mingxia, Xiong; Weichun, He; Li, Fang; Ping, Wen; Junwei, Yang

Yang, Zhou; Xiaohua, Wang; Lei, Jiang; Ruoyun, Tan; Mingxia, Xiong; Weichun, He; Li, Fang; Ping, Wen; Junwei, Yang.

Affiliation

Yang Z; Center of Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, China.

Am J Physiol Renal Physiol ; 299(2): F336-46, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20484295

Subject(s)

Epithelial Cells/enzymology; Fibronectins/metabolism; Hyperuricemia/enzymology; Kidney Tubules/enzymology; Protein-Lysine 6-Oxidase/metabolism; Uric Acid/metabolism; Animals; Blotting, Western; Cell Line; Disease Models, Animal; Epithelial Cells/drug effects; Epithelial Cells/pathology; Extracellular Matrix Proteins/metabolism; Fibrosis; Fluorescent Antibody Technique; Hyperuricemia/pathology; Kidney Tubules/drug effects; Kidney Tubules/pathology; Male; Mice; Mice, Inbred C57BL; NF-kappa B/metabolism; Organic Anion Transporters/antagonists & inhibitors; Organic Anion Transporters/genetics; Organic Anion Transporters/metabolism; Probenecid/pharmacology; Protein-Lysine 6-Oxidase/genetics; RNA Interference; Rats; Time Factors; Up-Regulation; Uric Acid/blood

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Fibronectins / Hyperuricemia / Epithelial Cells / Kidney Tubules / Protein-Lysine 6-Oxidase Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2010 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google