Chiral Induction by cinchona alkaloids in the rhodium(II) catalyzed O-H insertion reaction.
Chem Pharm Bull (Tokyo)
; 58(6): 872-4, 2010 Jun.
Article
in En
| MEDLINE
| ID: mdl-20523004
ABSTRACT
Cinchona alkaloids are effective additives for enantioselective O-H insertion of alpha-phenyldiazoacetate and water by rhodium(II) complexes. Addition of silica gel promotes O-H insertion in the reaction rate and the reaction proceeds smoothly at less than the freezing point of water, e.g., -10 degrees C, and provided mandelate in up to 50% ee. The results reported here are the highest asymmetric inductions obtained to date for O-H insertions via a Rh-carbenoid.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylacetates
/
Rhodium
/
Water
/
Cinchona Alkaloids
/
Coordination Complexes
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2010
Type:
Article