Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy.

Moes, Nicolette; Rieux-Laucat, Frédéric; Begue, Bernadette; Verdier, Julien; Neven, Bénédicte; Patey, Natacha; Torgerson, Troy T; Picard, Capucine; Stolzenberg, Marie-Claude; Ruemmele, Corinne; Rings, Edmond Hhm; Casanova, Jean-Laurent; Piloquet, Hugues; Biver, Armand; Breton, Anne; Ochs, Hans D; Hermine, Olivier; Fischer, Alain; Goulet, Olivier; Cerf-Bensussan, Nadine; Ruemmele, Frank M

Moes, Nicolette; Rieux-Laucat, Frédéric; Begue, Bernadette; Verdier, Julien; Neven, Bénédicte; Patey, Natacha; Torgerson, Troy T; Picard, Capucine; Stolzenberg, Marie-Claude; Ruemmele, Corinne; Rings, Edmond Hhm; Casanova, Jean-Laurent; Piloquet, Hugues; Biver, Armand; Breton, Anne; Ochs, Hans D; Hermine, Olivier; Fischer, Alain; Goulet, Olivier; Cerf-Bensussan, Nadine; Ruemmele, Frank M.

Affiliation

Moes N; Université Paris Descartes, Paris, France.

Gastroenterology ; 139(3): 770-8, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20537998

Subject(s)

Autoimmune Diseases/immunology; Forkhead Transcription Factors/blood; Intestinal Diseases/immunology; T-Lymphocytes, Regulatory/immunology; Age of Onset; Autoimmune Diseases/genetics; Autoimmune Diseases/mortality; Autoimmune Diseases/therapy; CD4 Lymphocyte Count; Case-Control Studies; Cells, Cultured; Child; Child, Preschool; Coculture Techniques; Down-Regulation; Female; Flow Cytometry; Forkhead Transcription Factors/genetics; Humans; Immunosuppressive Agents/therapeutic use; Infant; Infant, Newborn; Interleukin-2 Receptor alpha Subunit/blood; Interleukin-2 Receptor alpha Subunit/genetics; Intestinal Diseases/genetics; Intestinal Diseases/mortality; Intestinal Diseases/therapy; Male; Microscopy, Confocal; Mutation; Open Reading Frames; Parenteral Nutrition, Total; Promoter Regions, Genetic; RNA, Messenger/blood; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / T-Lymphocytes, Regulatory / Forkhead Transcription Factors / Intestinal Diseases Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Gastroenterology Year: 2010 Type: Article Affiliation country: France

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