Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma.

Richter-Larrea, Jose A; Robles, Eloy F; Fresquet, Vicente; Beltran, Elena; Rullan, Antonio J; Agirre, Xabier; Calasanz, Maria José; Panizo, Carlos; Richter, Jose A; Hernandez, Jesus M; Roman-Gomez, Jose; Prosper, Felipe; Martinez-Climent, Jose A

Richter-Larrea, Jose A; Robles, Eloy F; Fresquet, Vicente; Beltran, Elena; Rullan, Antonio J; Agirre, Xabier; Calasanz, Maria José; Panizo, Carlos; Richter, Jose A; Hernandez, Jesus M; Roman-Gomez, Jose; Prosper, Felipe; Martinez-Climent, Jose A.

Affiliation

Richter-Larrea JA; Division of Oncology, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.

Blood ; 116(14): 2531-42, 2010 Oct 07.

Article in En | MEDLINE | ID: mdl-20570860

Subject(s)

Apoptosis Regulatory Proteins/genetics; Burkitt Lymphoma/drug therapy; Burkitt Lymphoma/genetics; Drug Resistance, Neoplasm/drug effects; Gene Silencing/drug effects; Histone Deacetylase Inhibitors/therapeutic use; Membrane Proteins/genetics; Proto-Oncogene Proteins/genetics; Animals; Antibiotics, Antineoplastic/pharmacology; Bcl-2-Like Protein 11; Cell Line, Tumor; Doxorubicin/pharmacology; Gene Expression Regulation, Neoplastic/drug effects; Histone Deacetylase Inhibitors/pharmacology; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc/genetics; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins / Burkitt Lymphoma / Drug Resistance, Neoplasm / Gene Silencing / Apoptosis Regulatory Proteins / Histone Deacetylase Inhibitors / Membrane Proteins Limits: Animals / Humans Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: Spain

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